Dr. Bynthia Anose

Assistant Professor of Biochemistry

B.S. Bethel University

Ph.D. University of Minnesota

Research Interests

My research interests include the study of potential biomarkers for human reproductive cancers. My current area of investigation is prostate cancer (PCa). Human prostatic carcinoma accounts for 30% of cancer cases diagnosed in American men. The 5-year survival rate for a patient with localized PCa is 100%, but for those diagnosed with cancer that has spread to other parts of the body (metastasis), the survival rate drops to only 34%. This significant decline in prognosis with the onset of metastasis has highlighted the need for identifying metastatic biomarkers, in addition to currently utilized cancer transformation biomarkers. My previous research has identified zinc finger E-box binding homeobox-1 (ZEB-1) as a possible biomarker for PCa metastasis. The expression of this gene has been shown to be regulated by androgen and to change sharply at metastasis. The goal of my current work is to investigate the effects of flutamide (a clinical anti-androgen) and dihydrotestosterone (an androgen) on the expression of ZEB-1. Ongoing studies aim to confirm the feasibility of using ZEB-1 as a PCa metastatic biomarker, utilizing the cutting-edge biochemical technique known as real-time polymerase chain reaction.

Teaching Interests

My principal teaching interests lie in the area of Biochemistry. I have taught courses including: Biochemistry I and II, Principles of Biology, Introduction to General, Organic, and Biochemistry I and II, Chemistry Junior Seminar, The History of Science in Europe, and Forensics: The Science of Crime.

Brief Biography

I was born in India, grew up in Minnesota, and attended college and graduate school in the midwest (Bethel College, UW-Madison, U of MN). My favorite hobby is traveling and so, whenever possible, I try to see the country and the world. I visited Ecuador, the Galapagos Islands, Israel, Jordan, the Netherlands, and India as a Bethel student, and Spain, Portugal, and France as a graduate student. Within the past year, I have traveled to Italy, Switzerland, Germany, France, England, and Brazil, and have plans to see many other countries in the near future. I've also visited a number of U.S. cities on recent trips. When I am actually not traveling, I enjoy reading, writing, and playing tennis.

Recent Publications

Anose, B. M.; Benjamin, K.; O’Brien, K. and Kramer, M. “Elucidation of Androgenic Activity in the Prostate Cancer Cell Line 22Rv1.” Proc. 13th Intl. Congress Endo., 2009: 199-204.

Hurt, E.M.; Saykally, J.N.; Anose, B.M.; Kalli, K.R. and Sanders, M.M. “Expression of the ZEB1 (deltaEF1) transcription factor in human: additional insights.” Mol Cell Biochem. 2008 Nov;318(1-2):89-99. Epub 2008 Jul 12.

Anose, B.M.; LaGoo, L. and Schwendinger, J. “Characterization of Androgen Regulation of ZEB-1 and PSA in 22Rv1 Prostate Cancer Cells.” Adv Exp Med Biol. 2008; 617:541-6.

Anose, B.M.; Linnes, M.P. and Sanders, M.M. “Hormonal Regulation of ZEB-1 and Implication for Progression of Human Reproductive Cancers.” Hormonal Carcinogenesis. Li, J.J. and S.A. Li (eds.) volume 4. New York: Springer-Verlag, 2005: 455-461.

Anose, B.M.; Landry, M.M. and Sanders, M.M. “Investigating the Role and Regulation of ZEB-1 by Quantitative Real-Time PCR.” Proc. 12th Intl. Congress Endo., 2004: 1473-1478.

Anose, B.M. “What Do We Know About the Critical ZEB Family of Transcription Factors?” Focus on Zinc Finger Protein Research. Research Signpost: in press.

Anose, B.M. and Sanders, M.M. “Signal Transduction by Androgen Involves the Zinc-finger E-box Binding Protein (ZEB)-1.” in revision.