Chemistry Department
Dr. Bynthia Anose
Assistant Professor of Biochemistry
B.S. Bethel University
Ph.D. University of Minnesota
b-anose@bethel.edu, x6277
Research Interests
My research interests include the study of potential biomarkers for human reproductive cancers. My current area of investigation is prostate cancer (PCa). Human prostatic carcinoma accounts for 30% of cancer cases diagnosed in American men. The 5-year survival rate for a patient with localized PCa is 100%, but for those diagnosed with cancer that has spread to other parts of the body (metastasis), the survival rate drops to only 34%. This significant decline in prognosis with the onset of metastasis has highlighted the need for identifying metastatic biomarkers, in addition to currently utilized cancer transformation biomarkers. My previous research has identified zinc finger E-box binding protein (ZEB-1) as a possible biomarker for PCa metastasis. The expression of this gene has been shown to be regulated by androgen and to decrease sharply at metastasis. The goal of my current work is to investigate the effects of flutamide (a clinical anti-androgen) and dihydrotestosterone (an androgen) on the expression of ZEB-1. Ongoing studies aim to confirm the feasibility of using ZEB-1 as a PCa metastatic biomarker, utilizing the cutting-edge biochemical technique known as real-time polymerase chain reaction.
Teaching Interests
My principal teaching interests lie in the area of Biochemistry. I have taught courses including: Biochemistry I and II, Principles of Biology, Introduction to General, Organic, and Biochemistry I and II, Chemistry Junior Seminar, and Forensics: The Science of Crime.
Brief Biography
I was born in India, grew up in Minnesota, and attended college and graduate school in the midwest (Bethel College, UW-Madison, U of MN). My favorite hobby is traveling and so, whenever possible, I try to see the country and the world. I visited Ecuador, the Galapagos Islands, Israel, Jordan, and India as a Bethel student, and Spain, Portugal, and various other European countries as recent vacations. This Fall, I traveled to the French Riviera and Paris for a conference, and have many plans to see other countries in the near future. I've also visited a number of U.S. cities in my travels. When I am actually not traveling, I enjoy reading, writing, and playing tennis.
Recent Publications
LaGoo, L.M., Schwendinger, J.K., Anose, B.M. “Characterization of Androgen Regulation of ZEB-1 and PSA in 22Rv1 Prostate Cancer Cells.” Hormonal Carcinogenesis. Li, J.J. and S.A. Li (eds.) volume 5. New York: Springer-Verlag. (2007) in press
Anose, B.M. and Sanders, M.M. “Signal Transduction by Androgen Involves the Zinc-finger E-box Binding Protein (ZEB)-1.” (2007) in revision
Anose, B.M., Linnes, M.P., Sanders, M.M. “Hormonal Regulation of ZEB-1 and Implication for Progression of Human Reproductive Cancers.” Hormonal Carcinogenesis. Li, J.J. and S.A. Li (eds.) volume 4. New York: Springer-Verlag, 455-461 (2005).
Anose, B.M., Landry, M.M., and Sanders, M.M. “Investigating the Role and Regulation of ZEB-1 by Quantitative Real-Time PCR.” Proc. 12th Intl. Congress Endo., 1473-1478 (2004).
Anose, B.M. and Sanders, M.M. “The Androgen-regulated ZEB-1 Gene is a Biomarker for Metastatic Prostate Cancer.” 12th Intl. Mtg. Endo. Society, P-1016 (2004).
Anose, B.M. and Sanders, M.M. “Steroid Hormones Regulate Expression of Human ZEB-1: Implications for Cancer Progression.” Proc. Amer. Assoc. Cancer Res., (2nd ed.), 44:R5066 (2003).